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Computational Protein Engineer
Manufacturing
Rockville, MD
Location: Rockville, MD | Schedule: Full-time, on-site
Overview
A biotechnology organization focused on advanced protein and antibody engineering is seeking a Computational Protein Engineer. This role combines hands-on experimental leadership with computational design strategies to accelerate the development of novel protein and antibody therapeutics.
What you'll do
- Lead experimental design and execution of antibody and protein engineering programs, including affinity maturation, multi-specific antibody development, and de novo binder design
- Drive protein expression, purification, and characterization workflows across multiple formats
- Design and execute binding and functional assays to evaluate and iterate on engineered proteins
- Collaborate with structural biologists and computational scientists to integrate structural insights into experimental programs
- Apply computational tools such as AlphaFold and Rosetta to support and inform wet lab strategies
Required qualifications
- PhD in biochemistry, molecular biology, protein biochemistry, or related discipline
- Hands-on expertise in protein expression, purification, and characterization
- Experience with antibody engineering formats including bispecifics, nanobodies, or related modalities
- Peer-reviewed publications and/or patents in antibody or protein engineering
- Proven ability to lead technical teams and manage complex, multi-faceted projects
- Outstanding written and verbal communication skills
Preferred qualifications
- Familiarity with computational design tools (AlphaFold, Rosetta, ProteinMPNN) a plus
Why this role
This is an opportunity to lead hands-on experimental programs in antibody and protein engineering while leveraging cutting-edge computational tools to inform and accelerate design cycles.
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